Journal: BMC Cancer
Article Title: TGF-β signaling and tumor microenvironment dynamics in bladder cancer progression post-BCG therapy: a longitudinal single-nucleus RNA-seq study
doi: 10.1186/s12885-025-15079-8
Figure Lengend Snippet: Single-cell transcriptome analysis was performed on samples from 9 bladder cancer patients. A Baseline information of clinical features, along with cell abundance in cancer tissues from the 9 patients. B tSNE plot of 54,393 cells from the 9 patients, colored by their 6 major cell types. C tSNE plot showing cell distribution across progression states and pairwise comparisons of Primary vs. Progression samples for P-2, P-8, and P-9. D Expression patterns of marker genes for the six major cell types, displayed using tSNE plots. E Violin plots showing expression levels of marker genes across six major cell types
Article Snippet: To identify large-scale chromosomal copy number variations (CNVs) in single-cell RNA-Seq data of bladder cancers, including amplifications and deletions of whole or large chromosome segments, we used the InferCNV (version 1.10.1) ( https://github.com/broadinstitute/inferCNV ) software package.
Techniques: Expressing, Marker